Now showing items 1-10 of 50
Clozapine versus typical neuroleptic medication for schizophrenia
Background: Long-term drug treatment of schizophrenia with typical antipsychotics has limitations: 25 to 33% of patients have illnesses that are treatment-resistant. Clozapine is an antipsychotic drug, which is claimed to ...
Minor physical anomalies in patients with first-episode psychosis: Their frequency and diagnostic specificity
Background: An increased prevalence of minor physical anomalies (MPAs) has been extensively documented in schizophrenia but their specificity for the disorder remains unclear. We investigated the prevalence and the predictive ...
The challenge of recruiting people with schizophrenia to a health promotion trial
People with schizophrenia have an increased risk of coronary heart disease. This pilot study tested the feasibility of carrying out a randomised controlled trial to compare coronary heart disease prevention for this ...
Determining the chronology and components of psychosis onset: The Nottingham Onset Schedule (NOS)
The Nottingham Onset Schedule (NOS) is a short, guided interview and rating schedule to measure onset in psychosis. Onset is defined as the time between the first reported/observed change in mental state/behaviour to the ...
Parental loss before the age of 16 years: A comparative study of patients with personality disorder and patients with schizophrenia in a high secure hospital's population
There is a considerable body of literature supporting an association between separation from parent in childhood and later personality disorder. This study compares a 10-year cohort of high secure hospital patients who had ...
Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: Findings from the 3-center AESOP study
Context: Convention suggests uniformity of incidence of schizophrenia and other psychoses; variation would have implications for their causes and biological characteristics. Objective: To investigate variability in the ...