Psychosis and schizophrenia
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Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
(2020)BACKGROUND: Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ... -
Chlorpromazine versus atypical antipsychotic drugs for schizophrenia
(2020)Background: Chlorpromazine is an aliphatic phenothiazine, which is one of the widely‐used typical antipsychotic drugs. Chlorpromazine is reliable for its efficacy and one of the most tested first generation antipsychotic ... -
Early magnetic resonance imaging biomarkers of schizophrenia spectrum disorders: Toward a fetal imaging perspective
(2020)There is mounting evidence to implicate the intrauterine environment as the initial pathogenic stage for neuropsychiatric disease. Recent developments in magnetic resonance imaging technology are making a multimodal analysis ... -
Quantifying the core deficit in classical schizophrenia
(2020)Background: For more than 100 years, disorganization and impoverishment of mental activity have been recognised as fundamental symptoms of schizophrenia. These symptoms may reflect a core brain process underlying persisting ... -
Avatar Therapy for people with schizophrenia or related disorders
(2020)BACKGROUNDMany people with schizophrenia do not achieve satisfactory improvements in their mental state, particularly the symptom of hearing voices (hallucinations), with medical treatment.OBJECTIVESTo examine the effects ... -
Association of the extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls
(2020)BACKGROUND: First episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is consequent to patients being ... -
Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis
(2020)The associative striatum, an established substrate in psychosis, receives widespread glutamatergic projections. We sought to see if glutamatergic indices are altered between early psychosis patients with and without a ... -
Association between clusters of formal thought disorders severity and neurocognitive and functional outcome indices in the early stages of psychosis - Results from the pronia cohort
(2020)Background: Formal thought disorder (FThD) has been associated with more severe illness courses and functional deficits in psychosis patients. Given these associations, it remains unclear whether the presence of FThD ... -
Therapist self-disclosure in positive psychotherapy for psychosis
(2020)Setting boundaries is common in therapist self-disclosure. This qualitative study examined attitudes and experiences of therapists towards self-disclosure during a positive psychotherapy for psychosis research trial. ... -
The core of classical schizophrenia
(2020)Carpenter provides an incisive account of the evolution of the concept of schizophrenia in his commentary1 on my article2 about the core deficit of classical schizophrenia. He describes the way in which the Diagnostic and ... -
Acute interventions for aggression and agitation in psychosis: Study protocol for a systematic review network meta-analysis
(2019)INTRODUCTION: Individuals with psychosis may access emergency services due to aggression and agitation. When the de-escalation technique fails to achieve tranquillisation, several pharmacological options are available. ... -
Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: A machine learning approach
(2019)Background: Outcomes for people with first-episode psychosis are highly heterogeneous. Few reliable validated methods are available to predict the outcome for individual patients in the first clinical contact. In this ... -
Acute transient psychotic disorder precipitated by Brexit vote
(2019)A man in his 40s was brought to the accident and emergency department in an acute psychotic state, 3 weeks after the European Union referendum results in the UK were declared. His mental health had deteriorated rapidly ... -
Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange)
(2019)INTRODUCTIONMany patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ... -
Zotepine versus placebo for schizophrenia
(2013)This is the protocol for a review and there is no abstract. The objectives are as follows: To review the effects of zotepine compared with placebo for people with schizophrenia or related psychoses. As secondary objectives, ... -
The core deficit of classical schizophrenia: Implications for predicting the functional outcome of psychotic illness and developing effective treatments
(2019)Many people suffering from psychotic illnesses experience persisting impairment of occupational and social function. Evidence assembled since the classical description of schizophrenia over a century ago indicates that ... -
Prison vs. hospital for offenders with psychosis; effects on reoffending
(2019)With research showing a high prevalence of psychosis in prisons, its effective management is essential for clinical and criminal outcomes. In a matched sample of released prisoners and discharged patients with psychosis ... -
Attenuated post-movement beta rebound associated with schizotypal features in healthy people
(2019)Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a ... -
Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14-18 year-olds: Managing Adolescent first episode Psychosis: A feasibility study (MAPS)
(2019)BACKGROUND: Adolescent-onset psychosis is associated with more severe symptoms and poorer outcomes than adult-onset psychosis. The National Institute for Clinical Excellence (NICE) recommend that adolescents with first ... -
A meta-analysis taxonomizing empathy in schizophrenia
(2018)Background: Trait empathy is integral to relationship development and maintenance. Therefore, impairment in this ability can have an adverse effect on many domains of life including social, sexual, and marital. Previous ...
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