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dc.contributor.authorOrrell, Martin
dc.date.accessioned2019-04-24T15:06:08Z
dc.date.available2019-04-24T15:06:08Z
dc.date.issued2019
dc.identifier.citationGold, C., Eickholt, J., Assmus, J., Stige, B., Wake, J. D., Baker, F. A., Tamplin, J., Clark, I., Lee, Y. C., Jacobsen, S. L., et al. (2019). Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial. BMJ Open, 9 (3), pp.e023436.en
dc.identifier.other10.1136/bmjopen-2018-023436
dc.identifier.urihttps://repository.nottinghamshirehealthcare.nhs.uk/handle/123456789/3199
dc.description© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
dc.description.abstractINTRODUCTION: In older adults, dementia and depression are associated with individual distress and high societal costs. Music interventions such as group music therapy (GMT) and recreational choir singing (RCS) have shown promising effects, but their comparative effectiveness across clinical subgroups is unknown. This trial aims to determine effectiveness of GMT, RCS and their combination for care home residents and to examine heterogeneity of treatment effects across subgroups. METHODS AND ANALYSIS: This large, pragmatic, multinational cluster-randomised controlled trial with a 2x2 factorial design will compare the effects of GMT, RCS, both or neither, for care home residents aged 65 years or older with dementia and depressive symptoms. We will randomise 100 care home units with >/=1000 residents in total across eight countries. Each intervention will be offered for 6 months (3 months 2 times/week followed by 3 months 1 time/week), with extension allowed if locally available. The primary outcome will be the change in the Montgomery-Asberg Depression Rating Scale score at 6 months. Secondary outcomes will include depressive symptoms, cognitive functioning, neuropsychiatric symptoms, psychotropic drug use, caregiver burden, quality of life, mortality and costs over at least 12 months. The study has 90% power to detect main effects and is also powered to determine interaction effects with gender, severity and socioeconomic status. ETHICS AND DISSEMINATION: Ethical approval has been obtained for one country and will be obtained for all countries. Results will be presented at national and international conferences and published in scientific journals. TRIAL REGISTRATION NUMBERS: NCT03496675; Pre-results, ACTRN12618000156280.en
dc.description.urihttps://bmjopen.bmj.com/content/9/3/e023436en
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dc.subjectNursing homesen
dc.subjectDementiaen
dc.subjectDepressionen
dc.subjectMood disordersen
dc.subjectMusic therapyen
dc.titleMusic Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trialen
dc.typeArticleen


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