• Admin Login
    View Item 
    •   Evidence@NottsHC Home
    • Conditions and diseases
    • Neurological conditions
    • Neurological conditions
    • View Item
    •   Evidence@NottsHC Home
    • Conditions and diseases
    • Neurological conditions
    • Neurological conditions
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Beyond current research practice: Methodological consideration in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?)

    Thumbnail
    Date
    2019
    Author
    das Nair, Roshan
    Metadata
    Show full item record
    Abstract
    Rehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). The number of randomised controlled trials (RCTs) for rehabilitation interventions in MS has increased over the last two decades. The design, conduct and reporting quality of some of these trials could be improved. There are, however, some specific challenges that researchers face in conducting RCTs of rehabilitation interventions, which are often 'complex interventions'. This paper explores some of the challenges of undertaking robust clinical trials in rehabilitation. We focus on issues related to (1) participant selection and sample size, (2) interventions - the 'dose', content, active ingredients, targeting, fidelity of delivery and treatment adherence, (3) control groups and (4) outcomes - choosing the right type, number, timing of outcomes, and the importance of defining a primary outcome and clinically important difference between groups. We believe that by following internationally accepted RCT guidelines, by developing a critical mass of MS rehabilitation 'trialists' through international collaboration and by continuing to critique, challenge, and develop RCT designs, we can exploit the potential of RCTs to answer important questions related to the effectiveness of rehabilitation interventions.
    URI
    https://repository.nottinghamshirehealthcare.nhs.uk/handle/123456789/3321
    https://journals.sagepub.com/doi/10.1177/1352458519858271
    Collections
    • Neurological conditions

    Copyright © Nottinghamshire Healthcare NHS Foundation Trust 2017
    Contact Us
    Powered by KnowledgeArc
     

     

    Browse

    All of Evidence@NottsHCCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    Researcher Directory

    Researchers

    Administration Area

    Admin Login

    Copyright © Nottinghamshire Healthcare NHS Foundation Trust 2017
    Contact Us
    Powered by KnowledgeArc