Neurological conditions
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Regional brain correlates of beta bursts in health and psychosis: A concurrent electroencephalography and functional magnetic resonance imaging study
(2020)BACKGROUNDThere is emerging evidence for abnormal beta oscillations in psychosis. Beta oscillations are likely to play a key role in the coordination of sensorimotor information that is crucial to healthy mental function. ... -
The implementation of telehealth to assess, monitor and treat neurodevelopmental disorders: a systematic review
(2020)BACKGROUNDIn response to COVID-19 there is increasing momentum behind the development and delivery of telehealth. To assess the anticipated exponential growth in telehealth it is important we accurately capture how telehealth ... -
Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study
(2020)BACKGROUND: Neurogenic dysphagia is common and has no definitive treatment. We assessed whether pharyngeal electrical stimulation (PES) is associated with reduced dysphagia. METHODS: The PHAryngeal electrical stimulation ... -
Informing the development of a digital health platform through universal points of care: Qualitative survey study
(2020)BACKGROUNDEpilepsy, multiple sclerosis (MS), and depression are chronic conditions where technology holds potential in clinical monitoring and self-management. Over 5 years, the Remote Assessment of Disease and Relapse - ... -
Developing a fatigue programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) study
(2020)Introduction: Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and ... -
Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews
(2020)This meta-review aimed to synthesise evidence on psychosocial adjustment to multiple sclerosis, to identify available treatment models and services for recently diagnosed individuals, and to explore their effectiveness. ... -
Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT-3 performance in multiple sclerosis
(2020)Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. ... -
Post-stroke fatigue: A scoping review
(2020)Background: Post-stroke fatigue (PSF) is one of the most common and frustrating outcomes of stroke. It has a high prevalence and it can persist for many years after stroke. PSF itself contributes to a wider range of ... -
Health care professionals' views on using remote measurement technology in managing central nervous system disorders: Qualitative interview study
(2020)BACKGROUNDRemote measurement technologies (RMT) can be used to collect data on a variety of bio-behavioral variables, which may improve the care of patients with central nervous system disorders. Although various studies ... -
An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
(2020)Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, ... -
Machine learning as a diagnostic decision aid for patients with transient loss of consciousness
(2020)BackgroundTransient loss of consciousness (TLOC) is a common reason for presentation to primary/emergency care; over 90% are because of epilepsy, syncope, or psychogenic non-epileptic seizures (PNES). Misdiagnoses are ... -
Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review
(2020)Purpose: To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS). Method: We conducted a meta-ethnographic synthesis ... -
The notion of “invisibility” in people’s experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis
(2020)Purpose: Invisible symptoms have a negative impact on people living with Multiple Sclerosis (MS), related to the very notion that they are “unseen.” It is important to understand the notion of “invisibility” in MS, as ... -
Cognitive rehabilitation for attention and memory in people with multiple sclerosis: a randomized controlled trial (CRAMMS)
(2019)OBJECTIVE: To assess the clinical and cost-effectiveness of cognitive rehabilitation for attention and memory problems in people with multiple sclerosis. DESIGN: Multicentre, pragmatic, randomized controlled trial. SETTING: ... -
Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT
(2020)Background: People with multiple sclerosis have problems with memory and attention. The effectiveness of cognitive rehabilitation has not been established. Objectives: The objectives were to assess the clinical effectiveness ... -
Behavioural activation treatment for depression in individuals with neurological conditions: A systematic review
(2019)OBJECTIVETo evaluate the effectiveness of behavioural activation interventions for people with neurological conditions with comorbid depression, and explore content and adaptations.DATA SOURCESPsycINFO, MEDLINE, CINAHL, ... -
Volume changes after traumatic spinal cord injury in animal studies-a systematic review
(2019)There are limited data on the lesion volume changes following spinal cord injury (SCI). In this study, a meta-analysis was performed to evaluate the volume size changes of the injured spinal cord over time among animal ... -
Experience of identity change in people who reported a diagnosis of multiple sclerosis: A qualitative inquiry
(2019)Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person's sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to ... -
Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: Study protocol
(2019)Objectives To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population. Setting A single centre study, Malaysia. ... -
Beyond current research practice: Methodological consideration in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?)
(2019)Rehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). The number of randomised controlled trials (RCTs) for rehabilitation interventions in MS has increased ...
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