Neurological conditions
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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders
(2020)Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, ... -
Machine learning as a diagnostic decision aid for patients with transient loss of consciousness
(2020)BackgroundTransient loss of consciousness (TLOC) is a common reason for presentation to primary/emergency care; over 90% are because of epilepsy, syncope, or psychogenic non-epileptic seizures (PNES). Misdiagnoses are ... -
Experiences of adjustment to secondary progressive multiple sclerosis: a meta-ethnographic systematic review
(2020)Purpose: To provide an overview of the experiences and needs of patients adjusting to life after receiving a diagnosis of secondary progressive multiple sclerosis (SPMS). Method: We conducted a meta-ethnographic synthesis ... -
The notion of “invisibility” in people’s experiences of the symptoms of multiple sclerosis: a systematic meta-synthesis
(2020)Purpose: Invisible symptoms have a negative impact on people living with Multiple Sclerosis (MS), related to the very notion that they are “unseen.” It is important to understand the notion of “invisibility” in MS, as ... -
Cognitive rehabilitation for attention and memory in people with multiple sclerosis: a randomized controlled trial (CRAMMS)
(2019)OBJECTIVE: To assess the clinical and cost-effectiveness of cognitive rehabilitation for attention and memory problems in people with multiple sclerosis. DESIGN: Multicentre, pragmatic, randomized controlled trial. SETTING: ... -
Group cognitive rehabilitation to reduce the psychological impact of multiple sclerosis on quality of life: the CRAMMS RCT
(2020)Background: People with multiple sclerosis have problems with memory and attention. The effectiveness of cognitive rehabilitation has not been established. Objectives: The objectives were to assess the clinical effectiveness ... -
Behavioural activation treatment for depression in individuals with neurological conditions: A systematic review
(2019)OBJECTIVETo evaluate the effectiveness of behavioural activation interventions for people with neurological conditions with comorbid depression, and explore content and adaptations.DATA SOURCESPsycINFO, MEDLINE, CINAHL, ... -
Volume changes after traumatic spinal cord injury in animal studies-a systematic review
(2019)There are limited data on the lesion volume changes following spinal cord injury (SCI). In this study, a meta-analysis was performed to evaluate the volume size changes of the injured spinal cord over time among animal ... -
Experience of identity change in people who reported a diagnosis of multiple sclerosis: A qualitative inquiry
(2019)Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person's sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to ... -
Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: Study protocol
(2019)Objectives To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population. Setting A single centre study, Malaysia. ... -
Beyond current research practice: Methodological consideration in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?)
(2019)Rehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). The number of randomised controlled trials (RCTs) for rehabilitation interventions in MS has increased ... -
A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries
(2019)OBJECTIVEThis review aimed to determine the effectiveness of personal smart technologies on outcomes in adults with acquired brain injury.DATA SOURCESA systematic literature search was conducted on 30 May 2019. Twelve ... -
A meta-synthesis of qualitative studies on patients' views and experiences of Multiple Sclerosis diagnosis
(2019)Background and aims: The process of being diagnosed with multiple sclerosis (MS) can be long and frustrating for individuals, which may affect their perceptions of MS and future relationships with healthcare professionals. ... -
Modifiable risk factors for poor health outcomes in multiple sclerosis: The urgent need for research to maximise smoking cessation success
(2019)Tobacco smoking is a well-established risk factor for multiple sclerosis (MS) onset, progression and poor health outcomes in people with MS. Despite smoking being a modifiable risk factor, no research has been undertaken ... -
A group memory rehabilitation programme for people with traumatic brain injuries: The ReMemBrIn RCT
(2019)BACKGROUND: People with traumatic brain injuries (TBIs) commonly report memory impairments. These are persistent, debilitating and reduce quality of life, but patients do not routinely receive memory rehabilitation after ... -
Clinical and cost effectiveness of memory rehabilitation following traumatic brain injury: a pragmatic cluster randomized controlled trial
(2019)Objective: To evaluate the clinical and cost effectiveness of a group-based memory rehabilitation programme for people with traumatic brain injury. Design: Multicentre, pragmatic, observer-blinded, randomized controlled ... -
Multimodal coding and strategic approach in young and older adults' visual working memory performance
(2019)Visual working memory (WM) was investigated in young (18-35 yrs) and older (63-88 yrs) adults by assessing use of visual and verbal processing, and strategic approach. Experiment 1 comprised a visual interference paradigm, ... -
Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
(2019)The pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative ... -
Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex
(2019)Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with ... -
Assessment and management of cognitive problems in people with multiple sclerosis: A national survey of clinical practice
(2018)BACKGROUND: People diagnosed with Multiple Sclerosis often have cognitive problems. However, it is unclear how cognitive impairment is currently assessed and managed in the UK. AIMS: To understand current clinical practice ...
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