Neurological conditions
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Experience of identity change in people who reported a diagnosis of multiple sclerosis: A qualitative inquiry
(2019)Background: A diagnosis of multiple sclerosis (MS) can lead to changes to a person's sense of self. The aim of this study was to investigate the subjective experience of identity change and subsequent adjustment to ... -
Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: Study protocol
(2019)Objectives To measure the clinical, structural and functional changes of an individualised structured cognitive rehabilitation in mild traumatic brain injury (mTBI) population. Setting A single centre study, Malaysia. ... -
Beyond current research practice: Methodological consideration in MS rehabilitation research (is designing the perfect rehabilitation trial the Holy Grail or a Gordian knot?)
(2019)Rehabilitation is an essential aspect of symptomatic and supportive treatment for people with multiple sclerosis (MS). The number of randomised controlled trials (RCTs) for rehabilitation interventions in MS has increased ... -
A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries
(2019)OBJECTIVEThis review aimed to determine the effectiveness of personal smart technologies on outcomes in adults with acquired brain injury.DATA SOURCESA systematic literature search was conducted on 30 May 2019. Twelve ... -
A meta-synthesis of qualitative studies on patients' views and experiences of Multiple Sclerosis diagnosis
(2019)Background and aims: The process of being diagnosed with multiple sclerosis (MS) can be long and frustrating for individuals, which may affect their perceptions of MS and future relationships with healthcare professionals. ... -
Modifiable risk factors for poor health outcomes in multiple sclerosis: The urgent need for research to maximise smoking cessation success
(2019)Tobacco smoking is a well-established risk factor for multiple sclerosis (MS) onset, progression and poor health outcomes in people with MS. Despite smoking being a modifiable risk factor, no research has been undertaken ... -
A group memory rehabilitation programme for people with traumatic brain injuries: The ReMemBrIn RCT
(2019)BACKGROUND: People with traumatic brain injuries (TBIs) commonly report memory impairments. These are persistent, debilitating and reduce quality of life, but patients do not routinely receive memory rehabilitation after ... -
Clinical and cost effectiveness of memory rehabilitation following traumatic brain injury: a pragmatic cluster randomized controlled trial
(2019)Objective: To evaluate the clinical and cost effectiveness of a group-based memory rehabilitation programme for people with traumatic brain injury. Design: Multicentre, pragmatic, observer-blinded, randomized controlled ... -
Multimodal coding and strategic approach in young and older adults' visual working memory performance
(2019)Visual working memory (WM) was investigated in young (18-35 yrs) and older (63-88 yrs) adults by assessing use of visual and verbal processing, and strategic approach. Experiment 1 comprised a visual interference paradigm, ... -
Axonal degeneration and demyelination following traumatic spinal cord injury: A systematic review and meta-analysis
(2019)The pathophysiology of spinal cord injury (SCI) related processes of axonal degeneration and demyelination are poorly understood. The present systematic review and meta-analysis were performed such to establish quantitative ... -
Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex
(2019)Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in social cognition. We hypothesize that oxytocin, a neuropeptide with ... -
Assessment and management of cognitive problems in people with multiple sclerosis: A national survey of clinical practice
(2018)BACKGROUND: People diagnosed with Multiple Sclerosis often have cognitive problems. However, it is unclear how cognitive impairment is currently assessed and managed in the UK. AIMS: To understand current clinical practice ... -
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
(2018)The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which ... -
Development of human electrophysiological brain networks
(2018)Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the ... -
Potential diagnostic and prognostic value of serum and cerebrospinal fluid biomarkers in traumatic spinal cord injury: A systematic review
(2018)It remains unclear whether biomarkers in the serum or cerebrospinal fluid (CSF) can be used for diagnosis or prognosis of spinal cord injuries (SCI). Therefore, a systematic review was undertaken to evaluate the prognostic ... -
Effects of intermittent theta burst stimulation applied to the left dorsolateral prefrontal cortex on empathy and impulsivity in healthy adult males
(2018)Impulsivity and empathy are clinically relevant multi-dimensional concepts. Existing evidence suggests the left dorsolateral prefrontal cortex (LDLPFC) plays a crucial role in impulsivity and empathy. However, the ... -
Reliability of single and paired pulse transcranial magnetic stimulation parameters across eight testing sessions
(2018)Transcranial magnetic stimulation (TMS) is a popular method for measuring motor cortical excitability in healthy and clinical populations, and is often used as an outcome measure to explore changes following an intervention. ... -
Changes in electrophysiological markers of cognitive control after administration of galantamine
(2018)The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance ... -
Wearable technology in epilepsy: The views of patients, caregivers, and healthcare professionals
(2018)Purpose: In recent years, digital technology and wearable devices applied to seizure detection have progressively become available. In this study, we investigated the perspectives of people with epilepsy (PWE), caregivers ... -
Analysis of shared heritability in common disorders of the brain
(2018)Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide ...
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